王荣蛟;莫苏;袁再美;和世春;和少英;郭太情;刘萍;毛华明;
WANG Rongjiao;MOE MOE SWE;YUAN Zaimei;HE Shichun;HE Shaoying;GUO Taiqing;LIU Ping;MAO Huaming;College of Animal Science and Technology, Yunnan Agricultural University;Panzhihua Academy of Agriculture and Forestry Sciences;Kunming Center for Animal Disease Control and Prevention;

• 1:云南农业大学动物科学技术学院
• 2:攀枝花市农林科学研究院
• 3:昆明市动物疫病预防控制中心

摘要(Abstract)：

肠道微生物产生的代谢物是影响宿主健康的关键介质。肠道中细菌、真菌、原生动物分解各种膳食营养素而产生的小分子代谢物有益于宿主健康。微生物产生的色氨酸与宿主多种不同生理过程紧密关联，如宿主的生理防御、内稳态、肠道屏障免疫以及炎症性疾病等，但还不清楚这些色氨酸代谢物之间是否存在协同或竞争关系。因此，明确由微生物代谢产生色氨酸的作用机制将有助于进一步解释微生物代谢产物与肠道健康之间的关系。本文主要综述了肠道细菌、真菌、原生动物与色氨酸代谢的特点及其代谢产物在肠道免疫屏障中的作用，色氨酸代谢物作为关键信号分子在不同的肠道炎症疾病中维持肠道稳态的作用，色氨酸代谢物在宿主免疫调节中的作用，旨在探讨肠道微生物的色氨酸代谢物对宿主健康的潜在影响，为今后肠道微生物代谢与哺乳动物健康这一新兴领域的研究提供参考。
Metabolites produced by intestinal microorganisms are key mediators affecting host health. Intestinal flora plays many irreplaceable roles in animals. Bacteria, fungi, and protozoa in the gut break down various dietary nutrients and produce small molecular metabolites that benefit host health. The tryptophan metabolized by its symbiotic flora can be metabolized to produce many bioactive metabolites that are beneficial to host health and are closely related to a variety of different physiological health processes in the host, such as host physiological metabolic process defense, intestinal homeostasis,intestinal barrier immunity, and inflammatory diseases. It is not clear from the present study whether there is a synergistic or competitive relationship between these tryptophan metabolites. Therefore, a clear understanding of the mechanism of microbial metabolites of tryptophan origin will help to further explain the relationship between microbial metabolites and intestinal health. Intestinal microorganisms mainly include bacteria, fungi, protozoa, etc., which eventually form similar active metabolites through a complex process of tryptophan metabolism. This paper aims to explore the potential physiological function and mechanism of regulating tryptophan metabolites produced by intestinal microorganisms on host health. First,the characteristics of intestinal bacteria, fungi, protozoa and tryptophan metabolism and the role of their metabolites in the intestinal immune barrier are discussed. Secondly, tryptophan metabolites play a role in maintaining intestinal homeostasis as key signaling molecules in different intestinal inflammatory diseases. To provide guidance for future research in this emergingfield of intestinal microbial metabolism related to mammalian health.

关键词(KeyWords)： 肠道菌群;色氨酸代谢;免疫调节;宿主
Intestinal flora;Tryptophan metabolism;Immune regulation;Host

Abstract:

Keywords:

基金项目(Foundation): 云南省现代农业奶牛产业技术体系建设项目（2019K JTX0014）;; 国家自然科学基金（32060762）

作者(Authors): 王荣蛟;莫苏;袁再美;和世春;和少英;郭太情;刘萍;毛华明;
WANG Rongjiao;MOE MOE SWE;YUAN Zaimei;HE Shichun;HE Shaoying;GUO Taiqing;LIU Ping;MAO Huaming;College of Animal Science and Technology, Yunnan Agricultural University;Panzhihua Academy of Agriculture and Forestry Sciences;Kunming Center for Animal Disease Control and Prevention;

DOI: 10.19556/j.0258-7033.20210303-02

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