美国PRRSV 1-4-4 Lineage 1C新型变异株的基因组特征和传入我国的风险分析
梅隐;蒋旖瑶;周磊;杨汉春;
摘要(Abstract):
猪繁殖与呼吸综合征(Porcine Reproductive and Respiratory Syndrome,PRRS)是严重危害生猪产业的疾病之一,呈全球性流行,其病原猪繁殖与呼吸综合征病毒(Porcine Reproductive and Respiratory Syndrome Virus,PRRSV)具有毒株多样、易变异重组且异源毒株交叉保护不足的特点。2020年10月以来,在美国中西部地区发现一种新型PRRSV 1-4-4 Lineage 1C变异株,其较以往美国流行毒株致病性更强,感染可引起成年母猪死亡,传播更迅速,且现有疫苗对其保护效果不佳。鉴于中美间有大量种猪和猪肉制品贸易,且美国PRRSV毒株曾多次传入我国,该变异株的流行情况、基因组特征、致病性、传入风险以及现有检测方法和防控技术对其有效性等均成为业界关注重点。本文对新型PRRSV 1-4-4 Lineage 1C变异株在美国暴发和流行的情况、分子特征及传入我国的风险进行了总结分析,旨在提高对新型变异株的认识,加强防控技术储备,以保障我国养猪业安全稳定发展。
关键词(KeyWords):
PRRS;RFLP 1-4-4 Lineage 1C;基因组特征;毒株变异;传入风险
基金项目(Foundation): 国家自然科学基金(31772759);; 财政部和农业农村部:国家现代农业产业技术体系资助
作者(Authors):
梅隐;蒋旖瑶;周磊;杨汉春;
DOI: 10.19556/j.0258-7033.20210725-05
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