中国畜牧杂志

2022, v.58(05) 77-81

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菊粉对单胃动物肠道免疫功能的调节及应用研究进展
Research Progress on the Regulation and Application of Inulin on Intestinal Immune Function in Monogastric Animals

黄超勇;罗子林;黎力之;廖晓鹏;张海波;关玮琨;郭冬生;陈志斌;
HUANG Chaoyong;LUO Zilin;LI Lizhi;LIAO Xiaopeng;ZHANG Haibo;GUAN Weikun;GUO Dongsheng;CHEN Zhibin;College of Life Science and Resources and Environment,Yichun University;Engineering Technology Research Center of Jiangxi Universities and Colleges for Selenium Agriculture;Yichun Key Laboratory of Functional Agriculture and Ecological Environment,Yichun University;College of Continuing Education,Yichun University;Jiangxi Dongwang Animal Microbiology Co.,Ltd;

摘要(Abstract):

菊粉通过提高肠道益生菌竞争优势,增加肠黏膜蛋白和紧密连接蛋白分泌量,促进有益代谢产物短链脂肪酸和胆汁酸生成,活化G蛋白偶联受体,并抑制组蛋白去乙酰化酶活性,催化雷帕霉素靶蛋白、G蛋白偶联胆汁酸受体5和法尼醇X受体表达,降低核因子κB活性及其下游促炎细胞因子产生,调节肠道免疫机能。本文就菊粉对单胃动物肠道免疫功能的影响及其在动物生产中的应用进行综述,旨在为菊粉功能的深入探索和改善动物生产性能提供参考。
Inulin can increase the secretion of intestinal mucosal protein and tight junction protein by improving the competitive advantage of intestinal probiotics.Inulin promotes the production of beneficial metabolites,short chain fatty acids and bile acids,which activates G protein coupled receptors,inhibits histone deacetylase activity,and catalyzes the expression of rapamycin target protein,G protein coupled bile acid receptor 5 and farnesol X receptor.These reactions reduce nuclear factor kappa B activity and its downstream proinflammatory cytokines regulate intestinal immune function.This paper reviews the effect of inulin on intestinal immune function of monogastric animals and its application in animal production,in order to provide reference for further exploration of inulin function and improvement of animal production performance.

关键词(KeyWords): 菊粉;肠道菌群;短链脂肪酸;胆汁酸;肠道免疫
Inulin;Intestinal Imcroflora;Short-chain Fatty Acids;Bile Acid;Intestinal Immune

Abstract:

Keywords:

基金项目(Foundation): 国家地区科学基金项目(32060773);; 江西省自然科学基金(20202BABL205010);; 江西省现代农业产业技术体系建设专项资金(JXARS-14);; 江西省教育改革项目(JXJG-20-15-20);; 江西省教育厅项目(GJJ190848、GJJ201621)

作者(Authors): 黄超勇;罗子林;黎力之;廖晓鹏;张海波;关玮琨;郭冬生;陈志斌;
HUANG Chaoyong;LUO Zilin;LI Lizhi;LIAO Xiaopeng;ZHANG Haibo;GUAN Weikun;GUO Dongsheng;CHEN Zhibin;College of Life Science and Resources and Environment,Yichun University;Engineering Technology Research Center of Jiangxi Universities and Colleges for Selenium Agriculture;Yichun Key Laboratory of Functional Agriculture and Ecological Environment,Yichun University;College of Continuing Education,Yichun University;Jiangxi Dongwang Animal Microbiology Co.,Ltd;

DOI: 10.19556/j.0258-7033.20210331-04

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