袁欢;曹敞;黄若澜;杨梦豪;刘尊海;贾凯;孙超;
YUAN Huan;CAO Chang;HUANG Ruolan;YANG Menghao;LIU Zunhai;JIA Kai;SUN Chao;Northwest Agriculture and Forestry University;

• 1:西北农林科技大学

摘要(Abstract)：

姜黄素是一种源自中药姜黄的多酚类化合物，其具有羟基苯基和二酮结构，具有抗氧化和抗炎等多种药理性作用，能有效抑制氧化应激以及炎症的发生，降低畜禽代谢性疾病的发生率。本文重点总结了姜黄素在抗炎、抗氧化和抗病毒方面的生理功能、姜黄素作用的信号通路以及在代谢性疾病防治中的作用，并阐述了姜黄素在未来畜禽实际生产中可能的应用方式，为进一步推广姜黄素在畜禽养殖中的广泛应用提供参考。
Curcumin is a kind of polyphenol compound from turmeric,which has hydroxyphenyl and diketone structure,and has a great deal pharmacological roles such as anti-oxidation and anti-inflammatory.It can efficiently inhibit the emergence of oxidative stress and inflammation,and reduce the occurrence of metabolism diseases in livestock and poultry.This article focuses on summarizing the anti-inflammatory,antioxidant and antiviral physiological functions of curcumin,the signal pathway of curcumin action,and the role of metabolic disease prevention and treatment,and proposes the possible applications of curcumin in livestock and poultry production in the future.It provides a reference for further promoting the wide application of curcumin in livestock and poultry breeding.

关键词(KeyWords)： 姜黄素;抗氧化;抗炎;抗病毒;代谢性疾病
Curcumin;Antioxidant;Anti-inflammatory;Antiviral;Metabolic disease

Abstract:

Keywords:

基金项目(Foundation): 陕西省科技计划项目(2021NY-020);; 国家级创新训练计划(S202010712026)

作者(Authors): 袁欢;曹敞;黄若澜;杨梦豪;刘尊海;贾凯;孙超;
YUAN Huan;CAO Chang;HUANG Ruolan;YANG Menghao;LIU Zunhai;JIA Kai;SUN Chao;Northwest Agriculture and Forestry University;

DOI: 10.19556/j.0258-7033.20210424-02

参考文献(References)：

• [1]Pandey A,Chaturvedi M,Mishra S,et al.Reductive metabolites of curcumin and their therapeutic effects[J].Heliyon,2020,6(11):e05469.
• [2]Ahmed M,Qadir M A,Hameed A,et al.Screening of curcumin-derived isoxazole,pyrazoles,and pyrimidines for their anti-inflammatory,antinociceptive,and cyclooxygenase-2inhibition[J].Chem Biol Drug Des,2018,91(1):338-343.
• [3]Wang Y X,Zhang L,Wang P,et al.p H-shifting encapsulation of curcumin in egg white protein isolate for improved dispersity,antioxidant capacity and thermal stability[J].Food Res Int,2020,137:109366.
• [4]Yao Z,Liu H,Liu Y,et al.FRET-based fluorometry assay for curcumin detecting using PVP-templated Cu NCs.Talanta[J].2021,223(Pt2):121741.
• [5]Liu F,Gao S,Yang Y,et al.Antitumor activity of curcumin by modulation of apoptosis and autophagy in human lung cancer A549 cells through inhibiting PI3K/Akt/m TOR pathway[J].Oncol Rep,2018,39(3):1523-1531.
• [6]Parada E,Buendia I,Navarro E,et al.Microglial HO-1 induction by curcumin provides antioxidant,antineuroinflammatory,and glioprotective effects[J].Mol Nutr Food Res,2015,59(9):1690-1700.
• [7]Yang H,Du Z,Wang W,et al.Structure-activity relationship of curcumin:role of the methoxy group in anti-inflammatory and anticolitis effects of curcumin[J].Agric Food Chem,2017,65(22):4509-4515.
• [8]Zhang J F,Han H L,Shen M M,et al.Comparative studies on the antioxidant profiles of curcumin and bisdemethoxycurcumin in erythrocytes and broiler chickens[J].Animals,2019,9(11):953.
• [9]Rahban M,Habibi-Rezaei M,Mazaheri M,et al.Anti-viral potential and modulation of nrf2 by curcumin:pharmacological implications[J].Antioxidants (Basel),2020,9(12):1228.
• [10]李浩铭,黄永杰,王永丽,等.姜黄素及其代谢修饰产物对PC12细胞氧化损伤的保护作用[J].食品科学,2020,41(15):208-215.
• [11]Wang X X,Chang X H,Zhan H B,et al.Curcumin and baicalin ameliorate ethanol nduced liver oxidative damage via the Nrf2/HO pathway[J].J Food Biochem,2020,44(10):e13425.
• [12]Paciello F,Fetoni A R,Mezzogori D,et al.The dual role of curcumin and ferulic acid in counteracting chemoresistance and cisplatin-induced ototoxicity[J].Sci Rep,2020,10:1063.
• [13]Xie Z,Wu B,Shen G,et al.Curcum inalleviate sliver oxidative stress in type 1 diabetic rats[J].Mol Med Rep,2018,17(1):103-108.
• [14]Nawab A,Li G H,Liu W C,et al.Effect of dietary curcumin on the antioxidant status of laying hens under high-temperature condition[J].J Therm Biol,2019,86:102449.
• [15]陈明霞,方心灵,刘贤旭.姜黄素的生理功能及其在肉鸡生产上的应用研究进展[J].黑龙江畜牧兽医,2020(11):43-46.
• [16]Gacatig,Sabzevario,Wilsonjx,et al.Prooxidant activity and cellular effects of the phenoxyl radicals of dietary of lavonoids and other polyphenolics[J].Toxicology,2002,177(1):91.
• [17]李建设,何文龙,孟珂,等.姜黄素对LPS诱导的大鼠星形胶质细胞NF-κB炎症因子信号通路的影响[J].中国老年学杂志,2021,41(5):1081-1085.
• [18]Gan Z,Wei W,Li Y,et al.Curcumin and resveratrol regulate intestinal bacteria and alleviate intestinal inflammation in weaned piglets[J].Molecules,2019,24(7):1220.
• [19]Yu Y,Shen Q,Lal Y,et al.Anti-inflammatory effects of curcumin in microglial cells[J].Front Pharmacol,2018,9:386.
• [20]Ma F,Liu F,Ding L,et al.Anti-inflammatory effects of curcumin are associated with down regulating micro RNA-155in LPS-treated macrophages and mice[J].Pharm Biol,2017,55(1):1263-1273.
• [21]Daverey A,Agrawal Sandeep K.Curcumin protects against white matter injury through nf-κb and Nrf2 cross talk[J].J Neurotrauma,2020,37:1255-1265.
• [22]Hern Andez M,Wicz S,Caballero E P,et al.Dual chemotherapy with benznidazole at suboptimal dose plus curcumin nanoparticles mitigates Trypanosoma cruzi-elicited chronic cardiomyopathy[J].Parasitol Int,2020,22:102248.
• [23]Kim H,Ban I,Choi Y,et al.Puffing of Turmeric (curcuma longal.) enhances its anti-inflammatory effects by upregulating macrophage oxidative phosphorylation[J].Antioxidants (Basel),2020,9(10):931.
• [24]徐娟,陈卓锋,王治伟.姜黄素通过抑制NF-κB信号通路和NLRP3炎性体轴调控大鼠急性胰腺炎的研究[J].实用药物与临床,2020,23(8):693-698.
• [25]Balasubramanyam K,Varier R A,Altaf Mohammed,et al.Curcumin,a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase,represses the acetylation of histone/nonhistone proteins and his-tone acetyltransferasedependent chromatin transcription[J].J Biol Chem,2004,279:51163-51171.
• [26]Wei Z Q,Zhang Y H,Ke C Z,et al.Curcumin inhibits hepatitis B virus infection by down-regulating ccc DNA-bound histone acetylation[J].World J Gastroenterol,2017,23:6252-6260.
• [27]Teng C F,Yu C H,Chang H Y,et al.Chemopreventive effect of phytosomal curcumin on hepatitis b virus-related hepatocellular carcinoma in a transgenic mouse model[J].Sci Rep,2019,9:10338.
• [28]Babaei F,Nassiri-Asl M,Hosseinzadeh H.Curcumin (a constituent of turmeric):New treatment option against COVID-19[J].Food Sci Nutr,2020,8:5215-5227.
• [29]Li Y,Wang J,Liu Y,et al.Antiviral and virucidal effects of curcumin on transmissible gastroenteritis virus in vitro[J].Gen Virol,2020,101(10):1079-1084.
• [30]Patel A,Rajendran M,Shah A,et al.Virtual screening of curcumin and its analogs against the spike surface glycoprotein of SARS-Co V-2 and SARS-Co V[J].J Biomol Struct Dyn,2021:1-9.
• [31]Panahi Y,Hosseini M S,Khalili N,et al.Antioxidant and antiinflammatory effects of curcumin oid-piperine combination in subjects with metabolic syndrome:Arandomized controlled trial and an updated meta-analysis[J].Clin Nutr,2015,34(6):1101-1108.
• [32]Zhao D,Pan Y,Yu N,et al.Curcum in improves adipocytes browning and mitochondrial function in 3T3-L1cells and obese rodent model[J].R Soc Open Sci,2021,8(3):200974.
• [33]江丽青,李凯峰,翟蒙恩,等.四氢姜黄素对2型糖尿病小鼠糖脂代谢及大血管病变的影响[J].心脏杂志,2020,32(2):114-118.
• [34]Tang C,Li L,Shi J,et al.Curcumin in age-related diseases[J].Pharmazie,2020,75(11):534-539.
• [35]Lu M,Yin N,Liu W,et al.Curcumin ameliorates diabetic nephropathy by suppressing nlrp3 inflammasome signaling[J].Biomed Res Int,2017,2017:1516985.
• [36]Li P,Ding L Q,Cao S J,et al.Curcumin metabolites contribute to the effect of curcumin on ameliorating insulin sensitivity in high-glucose-induced insulin-resistant Hep G2cells[J].JEthnopharmacol,2020,259:113015.
• [37]陈洁,刘一然.姜黄素对2型糖尿病大鼠脂肪细胞葡萄糖转运及PI3K/AKT信号通路的影响[J].中国比较医学杂志,2019,29(5):90-97.
• [38]邓文荣,周志凌,李海俏,等,氧化应激与2型糖尿病大鼠肾脏损伤关系及其姜黄素干预[J].中国民族民间医药,2020,29(18):21-25.
• [39]Wu X,Huang L T,Zhou X L,et al.Curcumin protects cardiomyopathy damage through inhibiting the production of reactive oxygen species in type 2 diabetic mice[J].Biochem Biophys Res Commun,2020,530:15-21.
• [40]Xie Z,Wu B,Shen G,et al.Curcumin alleviates liver oxidative stress in type 1 diabetic rats[J].Mol Med Rep,2018,17(1):103-108.
• [41]Wu L Y,Chen C W,Chen L K,et al.Curcumin attenuates adipogenesis by inducing preadipocyte apoptosis and inhibiting adipocyte differentiation[J].Nutrients,2019,11(10):2307.
• [42]Zou H B,Sun X F,The mechanism of curcumin post-treatment relieving lung injuries by regulating mi R-21/TLR4/NF-κB signalling pathway[J].Int Med Res,2020,48:300060-520965809.
• [43]Kobori M,Takahashi Y,Takeda H,et al.Dietary Intake of curcumin improvese if2 signalingand reduces lipid levelsin the white adipose tissue ofobese mice[J].Sci Rep,2018,8(1):9081.
• [44]Kumar M,Sodhi K K,Singh D K,Addressing the potential role of curcumin in the prevention of COVID-19 by targeting the Nsp9 replicase protein through molecular docking[J].Arch Microbiol,2021,203(4):1691-1696.
• [45]Kritis P,Karampela I,Kokoris S,et al.The combination of bromelain and curcumin as an immune-boosting nutraceutical in the prevention of severe COVID-19[J].Metabol Open,2020,8:100066.
• [46]Saeedi-Boroujeni A,Mahmoudian-Sani M R,Bahadoram M,et al.COVID-19:a case for inhibiting NLRP3 inflammasome,suppression of inflammation with curcumin[J].Basic Clin Pharmacol Toxicol,2021,128:37-45.
• [47]Valizadeh H,Abdolmohammadi-Vahid S,Danshina S,et al.Nano-curcumin therapy,a promising method in modulating inflammatory cytokines in COVID-19 patients[J].Int Immunopharmacol,2020,89:107088.
• [48]Karandish M,Mozaffari-Khosravi H,Mohammadi S M.et al.Evaluation of the effect of curcumin and zinc co-supplementation on glycemic measurements,lipid profiles,and inflammatory and antioxidant biomarkers in overweight or obese prediabetic patients:a study protocol for a randomized doubleblind placebo-controlled phase 2 clinical trial[J].Trials,2020,21:991.